Major stock markets in Asia traded lower on Wednesday, amid uncertainties over global economic outlook after data showed US consumer confidence in August fell to an over six-year low. News that COVID-19 reinfection cases emerged in Europe and Asia also weighed on sentiment. Meanwhile, investors await the Fed’s chair Jerome Powell speech on Thursday. Stocks fell the most in China and Australia, while the Nikkei 225 eased from 6-month high, amid persisted local virus cases.