Stocks in the Asia-Pacific region closed mixed on Wednesday, amid Brexit uncertainty after British lawmakers passed the Withdrawal Agreement Bill to proceed through parliament but rejected the Brexit timetable on Tuesday. Also, news that China is preparing plans to replace embattled Hong Kong administrator Carrie Lam, on the back of months of political unrest, weighed on sentiment. Meantime, revenue warnings from Texas Instruments amid a prolonged US-China trade dispute, raised concerns about the global tech sector.